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Looks like it's a done deal:

Hillary Rodham Clinton has decided to give up her Senate seat and accept the position of secretary of state, making her the public face around the world for the administration of the man who beat her for the Democratic presidential nomination, two confidants said Friday.

Mrs. Clinton came to her decision after additional discussion with President-elect Barack Obama about the nature of her role and his plans for foreign policy, said one of the confidants, who insisted on anonymity to discuss the situation. Mr. Obama’s office told reporters Thursday that the nomination is “on track” but Clinton associates only confirmed Friday afternoon that she has decided.

“She’s ready,” said the confidant. Mrs. Clinton was reassured after talking again with Mr. Obama because their first meeting in Chicago last week “was so general,” the confidant said. The purpose of the follow-up talk, he added, was not to extract particular concessions but “just getting comfortable” with the idea of working together.